What happened with the drug thalidomide?

There isn't any doubt that prescription drugs make a positive change in a great number of peoples quality of life. Most of these drug treatments proceed through a significant extensive assessment as well as safe practices protocols before they come to market. Only a few medicines survive the assessment with many faltering and then they are discontinued by the drug business. The high standard expected before medications may be approved for the market ocurred as a result of rigorous requirements on account of prior problems, many of them being fairly spectacular. Just about the most renowned of those failures is probably the thalidomide debacle.

Thalidomide was first commercialized in 1957 in West Germany to take care of stress and anxiety, sleeping problems and also morning sickness in pregnancy. The thalidomide was very effective for the morning sickness in pregnancy and was speedily licensed in 46 nations to be used by women that were currently pregnant. Thalidomide was not licensed for marketing and distribution in the United States, in which it was declined by the Food and Drug Administration for not achieving high enough standards. This drug was never analyzed to determine if it was safe while pregnant. The outcome of thalidomides use in pregnancy was an estimated more than 10 000 children being born with a range of serious deformities and much more miscarriages. Of the live births just over half passed away within a few months of being given birth to. This is probably the leading controversy within the history of the prescription drug industry.

The issues with thalidomide were first recognized in 1961 by the Australian obstetrician, William McBride, that wrote a letter in the Lancet medical journal with regards to his findings of seeing an increase in the amount of disfigured children which were given birth to at his hospital, all of whom the mothers were having thalidomide. At approximately the same time, the paediatrician Widukind Lenz in Germany likewise documented many comparable instances where the medication was still sold over-the-counter and not simply on prescription. This resulted in an analysis and subsequent prohibiting of the drug from being used. In 1968, the German organization which made thalidomide, Chemie Grünenthal GmbH was placed on trial in Germany with the organization settling the case out of court and no case proceeding. On account of that the German affected individuals were compensated. No person from the company was found liable for any criminal offenses. In the UK, the victims of the medication had been also compensated by the UK distributors of the drug. In other countries there have been a number of class actions pursued, which results in pay outs a long time after the thalidomide discontinued to be marketed.

The publicity encircling this and the birth problems that took place from thalidomide cast a dark shadow all over prescription drug market. The resulting controversy led to every nation to produce considerably better systems for medication regulation and also tracking following the approval of medication. This is particularly the scenario in the terms of the use of medications during pregnancy where the guidelines and prerequisites are now very high.

Thalidomide as a drug nevertheless does have some uses for the management for cancer and some inflamation related conditions. It is getting used as a drug for leprosy and also myeloma.